100 75 50 25 O 12 Control Diet BPA Diet H 1 2 3 4 5 6 7 8 9

Last updated: 8/19/2023

100 75 50 25 O 12 Control Diet BPA Diet H 1 2 3 4 5 6 7 8 9 1 2 3 4 5 6 7 8 9 CG site number CG site number p 0 05 p 0 01 ne viable yellow allele has provided a valuable tool for investigating the impact of diet on epigenetic gulation of obesity since the Agouti gene also has a poorly understood role in body weight egulation A study published in 2007 Dolinoy et al Proc Nat Acad Sci USA 104 13056 13061 vestigated effects of BPA bisphenol A a chemical used in the manufacturing of plastics which is ssociated with elevated body weight and other adverse health outcomes in humans on methylation the IAP insertion in the viable yellow allele The figure above shows that mice with the viable ellow allele whose mothers were fed a BPA containing diet during pregnancy had significantly lower evels of methylation at multiple CG dinucleotides within IAP compared to mice whose mothers were ed a control diet What difference in fur color would you expect to see between mice in the two groups above mice whose mothers were fed control diet vs BPA diet Provide one sentence of rationale for your nswer based on what you know about the impact of CG methylation on gene expression including clear prediction regarding the expression level of the Agouti gene in the two groups