6 A 53 year old man seeks treatment for increasing fatigue

Last updated: 5/14/2023

6 A 53 year old man seeks treatment for increasing fatigue night sweats and bruising of his skin After extensive testing he is diagnosed with Philadelphia chromosome positive chronic myelogenous leukemia CML Because of his very high levels of leukocytes he is placed on induction therapy with hydroxyurea to reduce the white blood cell count before initiating treatment with inhibitors targeting the Bcr Abl tyrosine kinase Hydroxyurea targets an enzyme essential for nucleotide synthesis which one Answers A E A Dihydrofolate reductase B PRPP synthase