Cystic fibrosis is a Mendelian recessive allele The most common mutation associated with cystic fibrosis is the D F 508 mutation

Question

Cystic fibrosis is a Mendelian recessive allele The most common mutation associated with cystic fibrosis is the D F 508 mutation In the UK it is the most common cystic fibrosis variant accounting for 75 of cases However the worldwide frequency of cystic fibrosis associated mutations can vary greatly The frequency of the D F 508 mutation associated with cystic fibrosis in Romania was only 36 6 of cases Country United Kingdom Romania 9 408 9 996 AF 508 392 2 AF 508 AF 508 200 2 a Demonstrate the frequency of the D F 508 mutation is statistically significantly different between these two countries b Explain what could account for the differences if significant Question 2 5 pts Write the spreadsheet to calculate allele frequencies via the General Model of Selection a Calculate an example of selection against the recessive include plot b Calculate an example of selection favoring the homozygote include plot

Kunduz · Accepted Answer

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