Question 10 Antibody inhibition of RTK Function Antibodies are Y shaped molecules that carry two identical binding sites at the

Question

Question 10 Antibody inhibition of RTK Function Antibodies are Y shaped molecules that carry two identical binding sites at the end of the Y arms of the antibodies called the antigen binding sites Scientists have discovered or developed antibodies such as Herceptin a drug that is used to treat breast cancer that specifically bind to the extracellular domains of particular receptor tyrosine kinases When cells expressing a particular RTK are exposed to an antibody that binds to RTK one of three outcomes may occur 1 the antibody might cause activation 2 the antibody may block activation and 3 the antibody may not affect the function of the RTK Describe a molecular mechanism e g where does the antibody bind and what does it do that could explain each outcome

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