10 Although not as common as receptor tyrosine kinases, there are examples of cell division being regulated by growth factor binding to G-protein coupled receptors. Consider two related cell lines, A and B, both of which can be stimulated to divide by a

Last updated: 8/9/2022

Although not as common as receptor tyrosine kinases, there are examples of cell division being regulated by growth factor binding to G-protein coupled receptors. Consider two related cell lines, A and B, both of which can be stimulated to divide by a growth factor that binds to a G protein coupled receptor. This response can be mimicked in cell line A, but not cell line B, by the addition of ionomycin, a drug that makes membranes permeable to extracellular Cat+ ions. It's likely that cell line A responds to ionomycin treatment because growth factor binding to its receptor eventually induced activation of: Adenylyl cyclase. Protein Kinase C. Phosphatidylinositol. Protein Kinase A.