4 12pts A research study published in The Journal of

Last updated: 2/14/2024

4 12pts A research study published in The Journal of Biological Chemistry 2020 and mentioned in Science Daily 2020 discusses a drug that has been used in the treatment of SARS and MERS type coronaviruses Recent clinical trials were conducted by the NIH at the University of Nebraska Medical Center UNMC which is about 80 miles northeast of Doane University to test for its effectiveness towards combating the novel coronavirus COVID 19 Refer to the articles posted in module 4 and other resources you have at your disposal to answer the following questions Answer each part below accordingly a 1pt What is the name of the drug discussed b i 1pt Look up ie google and draw the structure of this drug ii 1pt How many carbon atoms in this structure are considered chiral c i 1pt What is the configuration of the chiral carbon which is not part of a ring Circle the correct label R or S below ii Using the structure drawn above label the priorities according to Cahn Ingold Prelog rules 1pt R or S d i 1pt How many additional stereoisomers does this compound have Note the phosphorous in this structure is also a stereocenter ii 2pts Propose a reason why the stereochemistry of this drug is important e 2pt What biochemical enzyme has this drug been shown to inhibit and why is this important f 2pt Draw the structure and provide a name of the RNA nucleotide that this drug most closely resembles