A GPCRs activate G proteins by reducing the strength of GDP binding allowing GDP to dissociate and GTP which is present in much

Question

A GPCRs activate G proteins by reducing the strength of GDP binding allowing GDP to dissociate and GTP which is present in much higher concentrations to bind What would happen if the affinity of Ga for GDP were reduced but the affinity for GTP remained unaffected Explain your reasoning make sure to explain the effect on amount of pathway signaling as compared to non mutated Ga and then why

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