A rat poison called Warfarin has been widely used in many cities including New York since the early 1950s Warfarin inhibits

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A rat poison called Warfarin has been widely used in many cities including New York since the early 1950s Warfarin inhibits blood coagulation A gene called VKORC1 is involved in the vitamin K reductase pathway which is involved in blood coagulation Animals homozygous for the VKORC1 allele are susceptible to poisoning by Warfarin Animals homozygous for the vkorc1 allele are resistant to the poison but have low survival rates because they cannot produce enough vitamin K Heterozygotes are intermediate in terms of warfarin susceptibility and vitamin K production Over time and exposure to Warfarin in New York the vkorc1 allele has increased in frequency but never to the exclusion of the VKORC1 allele What is being described in this scenario O Positive selection the vkorc1 allele has been selected for in New York O Negative selection the VKORC1 allele has been selected against in New York O Balancing selection the heterozygote has the highest fitness

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