Question:

Describe the mechanism by which ATP synthase makes ATP.

Last updated: 8/4/2022

Describe the mechanism by which ATP synthase makes ATP.

Describe the mechanism by which ATP synthase makes ATP. Protons flow with their concentration gradient into a half-channel in subunit a. Protons neutralize a glutamine residue in the center of a c-subunit, allowing it to enter the membrane. As one c-subunit enters the hydrophobic interior of the membrane, another exits and releases a proton through the second half- channel in subunit a into the mitochondrial matrix. Rotation of the c-ring rotates the attached alpha subunit. When the beta subunit is in the loose conformation, it may contain ATP. When the beta subunit is in the open conformation, ADP/Pi and ATP are able to diffuse freely in and out of the active site. When the beta subunit moves to the tight conformation, ADP and Pi are squeezed together to make ATP. TRUE FALSE TRUE