Here is an example JIGSAW slide We do not have a Group 1 so this is the Group assignment for Article 1 Reduced Permeability

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Here is an example JIGSAW slide We do not have a Group 1 so this is the Group assignment for Article 1 Reduced Permeability Darby E M Trampari E Siasat P et al Molecular mechanisms of antibiotic resistance revisited Nat Rev Microbiol 21 280 295 2023 GRAM NEGATIVE GRAM POSITIVE Purpose The purpose of this section was to discuss the bacterial adaptations to prevent antibiotics from crossing the cell membrane This section discusses Gram positive and negative mechanisms for reducing membrane permeability Concept Antibiotics usage has reduced cell permeability bacteria have evolved ways to prevent antibiotics from entering the cell The antibiotics cannot pass the cellular membranes of both Gram positive and negative cells which is a pathogenic tactic for resisting antibiotics Examples In some Gram negative species Enterobacterales E coli K pneumoniae porin channels have been modified to prevent larger molecules antibiotics from entering the cell P aeruginosa and A baumannii produce only small porins making their outer membranes highly impermeable Some pathogenic Gram positive bacteria have changed the composition of the cytoplasmic membrane which reduces permeability of the antibiotics

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