How do dominant mutations which cause disease manage to

Last updated: 6/15/2023

How do dominant mutations which cause disease manage to persist in human populations if natural selection acts strongly against individuals who have even one dom O There is such strong positive selection for positive alleles that such negative alleles do not matter O Some such alleles are do not manifest themselves until middle age after reproduction has likely occurred O Most alleles positive or negative are under neutral selective forces because there are so few genes when the entire 3 5 billion base pairs of the genome are co O Some very destructive dominant alleles which are few in number in the human population will not reach reach sufficient levels in frequency in the human pop selected out of the population