Mutations in the SLC26A2 gene causes disastrophic dysplasia an autosomal recessive condition Mutations in the FGFR3 gene causes

Question

Mutations in the SLC26A2 gene causes disastrophic dysplasia an autosomal recessive condition Mutations in the FGFR3 gene causes achondroplasia an autosomal dominant condition that is also lethal in the homozygous state Mary who suffers from anchondroplasia has a father who has diastrophic displasia and a mother with achondroplasia marries James who suffers from achondroplasia has a mother who has diastrophic dysplasia and a father with achondroplasia What is the chance that Mary and James will have a girl with only achondroplasia Provide a clearly labelled step by step account of your calculations DO NOT provide the pedigree 4 marks

Kunduz · Accepted Answer

Click to see the answer