O Macmillan Learning Hydrolysis of the N glycosyl bond between deoxyribose and a purine base in DNA creates an apurinic AP site

Question

O Macmillan Learning Hydrolysis of the N glycosyl bond between deoxyribose and a purine base in DNA creates an apurinic AP site An AP site is more thermodynamically destabilizing to a DNA molecule than is a mismatched base pair Examine the structure of an AP site H N HN N o Guanine 0 P O CH 0 N H HN H N N Select the chemical consequences that could contribute to DNA instability at AP sites fewer hydrogen bonds between the unpaired pyrimidine base and water decreased interaction between the mutated DNA strand and histones KH H H O VH disruption of the base stacking interactions increased ability of the deoxyribose ring to open without the attachment of the purine base H 6 6 O P O CH 0 OH Guanosine residue in DNA O H H H O Apurinic residue H H

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