pathogenicity and transmissibility and will continue to do so A point mutation first identified in the delta variant changed a

Question

pathogenicity and transmissibility and will continue to do so A point mutation first identified in the delta variant changed a leucine L or Leu at position 452 in the spike protein to an arginine R or Arg hence the name L452R This mutation increases the affinity of the spike protein for the viral receptor on human cells ACE2 allowing it to infect host cells more efficiently and making the virus more transmissible This is background information for questions 12 and 13 Use a codon table such as the one shown in Video 2 3 to deduce the nucleotide change that must have occurred in the spike protein coding sequence to change an Leu codon to a Arg codon bearing in mind this was a point mutation so only one nucleotide changed For example the answer choice below described as C A means a C nucleotide in the original viral sequence changed to an A in the delta variant OG C OC A OT G OT C Question 14 5 pts

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