Tay Sachs is a lysosomal storage disease that is inherited in an autosomal recessive manner. Individuals with Tay Sachs have a

Question

Tay Sachs is a lysosomal storage disease that is inherited in an autosomal recessive manner. Individuals with Tay Sachs have a defect in the gene encoding hexosaminidase A, a lysosomal enzyme that breaks down cell membrane components called gangliosides. The inability to break down gangliosides causes harmful quantities of this lipid to accumulate in nerve cells of the brain, eventually leading to premature death of affected cells. There is no known cure for the disease, and death usually occurs by age 4. Jack and Jill have a child who has Tay-Sachs. What do you know about the genotypes of Jack and Jill? (T= dominant allele; t = recessive allele) offspring? O Both areheterozygous One is TT and the otheris tt Both are TT Both are tt O Its impossible to tell. Sinceboth are adults, they do not have the disease. But, they could either beTT or Tt

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