Which of the following is not true about nucleophilic acyl

Last updated: 7/24/2022

Which of the following is not true about nucleophilic acyl substitution reactions with an acid anhydride (assuming that the required acid or base catalyst is present when needed)? Ammonia can serve as the nucleophile reacting with the anhydride to form an amide Chloride ion can serve as the nucleophile reacting with the anhydride to form an acyl chloride Water (with heat) can serve as the nucleophile reacting with the anhydride to form carboxylic acids Methanol can serve as the nucleophile reacting with the anhydride to form a methyl ester