You are interested in how cyclic AMP dependent protein kinase A PKA functions to affect learning and memory and you decide to

Question

You are interested in how cyclic AMP dependent protein kinase A PKA functions to affect learning and memory and you decide to study its function in the brain It is known that in the cells you are studying PKA works via a signal transduction pathway like the one depicted in Figure 16 15 Furthermore it is also known that activated PKA phosphorylates the transcriptional regulator called Nerd that then activates transcription of the gene Brainy Which situation described below will lead to an increase in Brainy transcription 22 a activated GPCR adrenergic receptor C inactive PKA CYTOSOL NUCLEUS GTP cyclic AMP nuclear pore active PKA activated phosphorylated transcription regulator ATP active PKA C inactive transcription regulator activated target gene Figure 16 15 TRANSCRIPTION OF TARGET GENE a mutation in the gene that encodes adenylyl cyclase that renders the enzyme unable to interact with the a subunit of the G protein b a mutation in the Nerd gene that produces a protein that cannot be phosphorylated by PKA a mutation in the nuclear import sequence of PKA that slows its import into the nucleus d a mutation in the gene that encodes the a subunit of the G protein that

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