Biology You are working in a lab to investigate immune

Last updated: 5/15/2023

Biology You are working in a lab to investigate immune responses to liver cancer caused by an oncogenic virus that infects hepatocytes liver cells Wild type mice develop small tumors when they are infected by this virus When mutant mice that lack RAG recombinases are infected by this virus they develop large tumors that quickly become lethal You transplant cells from lymph nodes of tumor bearing RAG deficient mice into wild type mice and two weeks later you infect the transplanted mice with the virus You observe that tumors do not develop at all in transplanted wild type mice Which of the following is the MOST likely explanation for this observation Group of answer choices The tumor cells have upregulated PD L1 and PD L2 checkpoint ligands Transplanted dendritic cells cross presenting tumor antigens activated CTLS in the recipient mice which carried out effective immunosurveillance Transplanted CTLs carried out effective immunosurveillance Transplanted helper T cells induced B cell class switching leading to antibody dependent cell mediated cytotoxicity ADCC The tumor cells are producing TGF beta