A reciprocal translocation between Chromosome 9 and Chromosome 22 produces the so called Philadelphia chromosome which causes

Question

A reciprocal translocation between Chromosome 9 and Chromosome 22 produces the so called Philadelphia chromosome which causes chronic myelogenous leukemia CML a cancer of white blood cells The translocation results in production of a protein that is no longer regulated but rather always active This leads to uncontrolled cell division in white blood cells Although this cancer always involves translocations between chromosomes 9 and 22 the BCR ABL protein that is the result of this translocation can vary in size contains 185 220 amino acids because the exact DNA bases where the chromosome breaks can vary Part 1 In any ONE patient will the BCR ABL fusion proteins isolated from a single tumor be the same size or varying sizes O Same size O Both same and varying sizes are possible O Varying sizes Part 2 If samples are taken from 100 patients will the BCR ABL protein in the cancerous white blood cells be the same size or of varying sizes Pick the most likely answer O All patients will have an BCR ABL protein of the same size O All patients will have BCR ABL proteins of varying sizes O Some patients may have the same size others will have varying sizes of the BCR ABL protein

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