Biology You are working in a lab that is studying mice that

Last updated: 5/15/2023

Biology You are working in a lab that is studying mice that are genetically prone to developing a condition similar to multiple sclerosis a disease in which autoreactive CD4 T cells cause pathology in the central nervous system You notice that a very high rate of mice that are infected with rotavirus a virus that infects the gastrointestinal tract go on to develop multiple sclerosis like symptoms Which of the following is the MOST likely mechanism underlying this observation Group of answer choices The rotavirus infection leads to T cell exhaustion that limits autoimmune disease relapse Monocytes and macrophages activated by the rotavirus infection traffic to the central nervous system and cause pathology there The rotavirus infection leads to the production of IgA antibodies that cross reactively recognize antigens in the central nervous system The rotavirus infection interferes with negative selection of autoreactive B cells in the bone marrow The rotavirus infection leads to an influx of PRR ligands from the gut leading to upregulation of co stimulatory molecules on DCs presenting self antigens from