Biomed Anal 53 2010 376 81 Stability testing is a crucial step in the development of drugs The conditions and time that a drug

Question

Biomed Anal 53 2010 376 81 Stability testing is a crucial step in the development of drugs The conditions and time that a drug will maintain its properties can impact its storage and shelf life as well as dosing of the drug Bupropion is the fourth most prescribed antidepressant however there are known issues with its stability To gain more information about its overall stability researchers have conducted studies to measure the stability of bupropion at different temperatures and pH s bupropion 1 Three different plots of the decomposition of 1 M bupropion over time at pH 11 and 30 C are shown below 16 bupropion m 0 8 0 6 0 4 0 2 0 0 50 0 5021 50 100 0 2521 100 Time hrs 150 200 In bupropion 0 0 5 1 5 2 2 5 3 0 50 0 689 50 Name 100 1 378 100 Time hrs 150 200 1 bupropion 1 M 12 a From the graphs above what is the reaction order circle zero order b Use the data above to determine the value of the rate constant including UNITS 0 0 100 3 967 50 1 992 50 first order 100 Time hrs HN 150 CH 200 second order c What will the concentration of bupropion be after 100 hours if the initial bupropion concentration is 2 5 M

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