Case 2 Polycystic Kidney Disease dominant lethal allele

Last updated: 5/14/2023

Case 2 Polycystic Kidney Disease dominant lethal allele Maria is 38 years old She and her husband Joe have 4 children Maria has been diagnosed with polycystic kidney disease She learns that cysts developing in her kic have damaged them severely The damage will continue until the kidneys stop functioning Maria faces dialysis and will eventually need a kidney transplant Maria is tested for the allele that causes the disease and learns that her form of the disease is caused by a dominant mutation on chromosome 16 Maria is heterozygous for the trait Her husband is confirmed to be homozygous recessive Maria s children offer the best hope of a match for a future kidney donation but must be free of the harmful allele 5 What is the probability of Maria and Joe s children inheriting this dominant harmful allele Solve a Punnett Square to estimate this probability Show your work below I INCOMPLETE DOMINANCE There are some situations in which the two alleles of a gene produce a blended effect in a heterozygous individual Because neither allele is dominant over the other capital