DNA polymerase contains an arginine residue that is important for binding to DNA. Mutations were found that converted this

Question

DNA polymerase contains an arginine residue that is important for binding to DNA. Mutations were found that converted this arginine to either glutamate, lysine, glycine and valine. Which mutations would be predicted to be the most and least harmful for the activity of the enzyme to bind DNA? Most: Lysine, least: Glutamate Most: Glutamate, least: Lysine Most: Glycine, least: Valine Most: Valine, least: Glycine.

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