Question:
How does mitogen binding to a Receptor Tyrosine Kinase (RTK)
Last updated: 7/23/2022
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How does mitogen binding to a Receptor Tyrosine Kinase (RTK) lead to the activation of Ras? The RTK recruits cytosolic Ras to the membrane. The RTK recruits both Ras and Ras-GEF from the cytosol to the membrane. The RTK activates MAPKKK, which phosphorylates and activates Ras. The RTK phosphorylates the GDP bound by inactive Ras. The RTK recruits cytosolic Ras-GEF to the membrane.