In sickle cell anemia, a mutation occurs and glutamic acid

Last updated: 7/29/2022

In sickle cell anemia, a mutation occurs and glutamic acid is replaced by valine. What effect would you expect to observe? Since glutamic acid is a polar and valine is nonpolar, the protein would now change its orientation and move towards the interior in aqueous solution. Since glutamic acid is a polar and valine is nonpolar, the protein would now change its orientation and move towards the exterior in aqueous solution. Since glutamic acid and valine are both nonpolar amino acids, both residues would move toward the interior in aqueous solution. Since glutamic acid and valine are both polar amino acids, both residues would move towards the exterior in aqueous solution.