Individuals with sickle cell anemia are homozygous for the

Last updated: 7/31/2022

Individuals with sickle cell anemia are homozygous for the gene Hbs, which specifies an altered hemoglobin molecule. The red blood cells of afflicted individuals become sickle shaped when deoxygenated, impeding blood flow and lysing. The allele Hbs is codominant with the allele Hb" for normal hemoglobin, i.e. in the heterozygous individual both normal and altered hemoglobin are produced. Under everyday circumstances heterozygous individuals are outwardly phenotypically indistinguishable from individuals homozygous for normal hemoglobin. A husband and wife phenotypically normal had a son with sickle cell anemia. a What are the genotypes of the husband and wife? b What is the probability that the couple's second child would have sickle cell anemia?