Researchers hypothesize that the plant compound resveratrol improves mitochondrial function. To test this hypothesis,

Question

Researchers hypothesize that the plant compound resveratrol improves mitochondrial function. To test this hypothesis, researchers dissolve resveratrol in dimethyl sulfoxide (DMSO). The solution readily passes through cell membranes. They add the resveratrol solution to mammalian muscle cells growing in a nutrient-rich solution (culture medium) that contains glucose. They measure ATP production at several time points after the addition of the resveratrol solution and find an increase in ATP production by the muscle cells. (a) Describe the primary advantage for a mammalian muscle cell in using aerobic respiration over fermentation. (b) Identify an appropriate negative control for this experiment that would allow the researchers to conclude that ATP is produced in response to the resveratrol treatment. (c) Predict the effect on short-term ATP production when resveratrol-treated mammalian muscle cells are grown in a culture medium that lacks glucose or other sugars.

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