Tetanus toxin is a highly potent toxin produced by the

Last updated: 7/13/2022

Tetanus toxin is a highly potent toxin produced by the clostridial family of bacterium (Clostridium tetani). Like botulinum toxin, tetanus toxin binds to the presynaptic motor nerve terminal. You and your lab partner use a living nerve and muscle preparation to study muscle contraction. When you stimulate the nerve electrically, the muscle contracts. When you add Tetanus toxin to your preparation, the muscle contracts but then remains contracted and stops responding to the electric stimulus, why? Tetanus toxin prevents the binding of ACh Tetanus toxin disrupts the release of presynaptic vesicles Tetanus toxin disrupts the release of ACh leading to continious stimulation