The pyruvate dehydrogenase complex (PDC) catalyzes the

Last updated: 7/31/2022

The pyruvate dehydrogenase complex (PDC) catalyzes the conversion of pyruvate to acetyl-CoA, a substrate for the Krebs (citric acid) cycle. The rate of pyruvate conversion is greatly reduced in individuals with PDC deficiency, a rare disorder. (a) Identify the cellular location where PDC is most active. (b) Make a claim about how PDC deficiency affects the amount of NADH produced by glycolysis AND the amount of NADH produced by the Krebs (citric acid) cycle in a cell. Provide reasoning to support your claims based on the position of the PDC-catalyzed reaction in the sequence of the cellular respiration pathway.