The Ras oncogene is activated by mutation of its proto

Last updated: 8/19/2023

The Ras oncogene is activated by mutation of its proto oncogene precursor in about 30 of all human cancers Use the dropdown menus to indicate yes or no for several possible genetic or epigenetic changes in the Ras gene described below to indicate whether you would you expect to find this change in tumor cells where one of the drivers is a Ras oncogene Deletion of one copy of the gene Select V Methylation of CG dinucleotides in the promoter region Select A translocation that moves the coding region of Ras near a repressor DNA element such that Ras is not transcribed Select A missense mutation that causes Ras protein to be constitutively active GTP bound in the absence of activating signals Select A copy number variant that locally amplifies the Ras gene Select Acetylation of histones associated with the Ras gene Select