Under appropriate conditions hemoglobin dissociates into its

Last updated: 2/21/2023

Under appropriate conditions hemoglobin dissociates into its four subunits The isolated a subunit binds oxygen but the O saturation curve is hyperbolic rather than sigmoid In addition the binding of oxygen to the isolated a subunit is not affected by the presence of H CO or BPG What do these observations indicate about the source of the cooperativity in hemoglobin Individual subunits are capable of binding O cooperatively BPG regulates the cooperative behavior of hemoglobin Cooperativity arises from the bicarbonate buffer system The cooperative behavior of hemoglobin arises from subunit interactions