Which ONE gives the commonly observed defect in cancer cells after both RB1 genes are mutated resulting in the genotype rb1 rbi

Question

Which ONE gives the commonly observed defect in cancer cells after both RB1 genes are mutated resulting in the genotype rb1 rbi O A PRB is no longer produced as a gene product cancer cells lack pRB OB transcription of RB1 gene is upregulated increasing the rate of production of pRB in cancer cells O C pRB mis folds causing its E2F binding site to exclude E2F OD the product of rb1 gene is capable of binding substantially more E2F than normal O E upstream regulators of pRB including Ras become constitutively activated

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