Which one is the basis of a tumor achieving a malignant

Last updated: 5/15/2023

Which one is the basis of a tumor achieving a malignant status as is evident in the progression of a benign colon polyp to malignant colon cancer A multiple mutations to proto oncogenes and or tumor suppressor genes B over expression of mitogen receptors OC heterozygosity of the tumor suppressor gene RB1 D activation of DNA replication during S phase O E genes of effectors down stream from Ras D and the RB1 gene