Helicases are proteins that "unzip" double stranded DNA to produce two, unbound single-strands of DNA. Some helicases initially

Question

Helicases are proteins that "unzip" double stranded DNA to produce two, unbound single-strands of DNA. Some helicases initially bind to double-stranded DNA, while other helicases initially bind to single-stranded DNA and then unzip the double-stranded DNA in front of them. Viruses are particularly dependent on helicases for viral replication. What features in DNA would be recognized by each of these two classes of helicases that would allow them to be specific?

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