In the slowest rate determining step of the reaction

Last updated: 5/9/2023

In the slowest rate determining step of the reaction mechanism for citrate synthase what is the role of the histidine OXC Oxaloacetate CH COO HC C SCA H CO 70XC CH HC C SCA Coo HO O Nucleophilic attack on oxaloacetate O Stabilize the enolate intermediate through hydrogen bonding O Hydrolysis of acetyl CoA O Induce a pKa shift in citrate 0