sherry inherited an Rb mutant copy from her mom and a wild

Last updated: 7/30/2022

sherry inherited an Rb mutant copy from her mom and a wild type copy from her dad. is she at high risk of getting a tumor? a. yes bc rb is a tumor suppresor gene (TSG) that needs hits on both of the alleles to stop functioning. if one of the hits has already been inherited then it is easy to get the mutation on a good copy and inactivate the gene b. no there is no difference in risk between someone with two good copies vs just one good copy c. yes bc rb is a TSH and one hit causes cell division that is not regulated