Which one is a classic example of loss of heterozygosity O A spontaneous mutation of the retinoblastoma gene RB1 to mutant

Question

Which one is a classic example of loss of heterozygosity O A spontaneous mutation of the retinoblastoma gene RB1 to mutant recessive allele rb1 B mis folding of Ras protein to a constitutively active state OC reciprocal translocation of SRY to X chromosome OD non disjunction in somatic cells O E absence of PARS pseudoautosomal regions on Y chromosome

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